Endocrine Abstracts

The growth of prostate cancer (PCa) can be suppressed by androgen deprivation therapy (ADT). However, in a significant proportion of men receiving ADT PCa progresses to castration-resistant prostate cancer, associated with activation of intratumoral androgen biosynthesis and induced androgen receptor (AR) expression. Accordingly, we have recently shown that the castration-resistant VCaP (CR-VCaP) xenografts express high level of AR and retain detectable intratumoral androgen c...

: Hydroxysteroid (17beta) dehydrogenases (HSD17Bs) form a group of enzymes that are characterized by their sequence similarity at the active site, and their ability to catalyze the conversion between the weak 17keto- and the highly active 17beta-hydroxysteroids. To study the physiological role of HSD17B13, a lipid droplet associated protein, we characterized the phenotype of knockout (KO) mice deficient in HSD17B13 (HSD17B13KO). The data revealed normal serum sex steroid conce...